Ferris picked up a cartilage injury to his right knee during the Ulster Heineken Cup game against Aironi and was unable to train with the Ireland squad last week during the Limerick camp.
The knee did not respond to the rest period and Ferris was referred to the knee specialist, who confirmed yesterday evening that while the injury did not require surgery he would not be available for the Italy game.
Ferris will continue with his rehabilitation and while there remains a doubt regarding his availability for the France game, he has not been ruled out of a return to play in time for selection.