Rhys Ruddock leads the team for the first time in a back-row which also includes Dominic Ryan and Stephen Keogh.
Ian Madigan makes his 11th appearance of the season and partners Paul O'Donohoe at half back with Eoin O'Malley, fresh from his Ireland Wolfhounds debut, lining up alongside debutant Brendan Macken at centre.
In the pack, Heinke van der Merwe and Richardt Strauss are named in the front row, with Kevin McLaughlin lining up at second row alongside fellow Ireland international Devin Toner.
Paul Ryan or Shane Jennings will take the final place on the replacements bench. A decision will be made closer to kick off.
Leinster team to play Aironi on Thursday night in the Magners League at the RDS:
Isa Nacewa, Andrew Conway, Brendan Macken, Eoin O'Malley, David Kearney, Ian Madigan, Paul O'Donohoe,
Heinke van der Merwe, Richardt Strauss, Clint Newland, Kevin McLaughlin, Devin Toner, Rhys Ruddock, Dominic Ryan, Stephen Keogh
Replacments: Jason Harris-Wright, Jack McGrath, Simon Shawe, Ed O'Donoghue, Paul Ryan/Shane Jennings, Isaac Boss, Ian McKinley, Niall Morris
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